OpenMandible: An open-source framework for highly realistic numerical modelling of lower mandible physiology

Computer modeling of lower mandible physiology remains challenging because prescribing realistic material characteristics and boundary conditions from medical scans requires advanced equipment skill sets. The objective this study is to provide a framework that could reduce simplifications made inconsistency (in terms geometry, materials, conditions) among further studies on the topic. OpenMandible offers: 1) first publicly available multiscale model developed by combining cone beam computerized tomography (CBCT) ?CT imaging modalities, 2) C++ software tool for generation simulation-ready models (tet4 hex8 elements). In addition application conventional (Neumann Dirichlet) conditions, introduces novel geodesic wave propagation - based approach incorporating orthotropic micromechanical cortical bone, unique algorithm muscles as uniformly directed vectors. base intact includes (spongy compact bone), 14 teeth (comprising dentin, enamel, periodontal ligament, pulp), simplified temporomandibular joints, masticatory (masseter, temporalis, medial, lateral pterygoid). complete source code, executables, showcases, sample data are freely public repository: https://github.com/ArsoVukicevic/OpenMandible. It has been demonstrated slightly editing baseline model, one can different “virtual” treatments or diseases, including tooth restoration, placement implants, bone degradation, others. eases community undertake broad range topic, while increasing their consistency reproducibility. At same time, needs dedicated skills developing simulation significantly reduced.